Utility-Weighted Modified Rankin Scale Scores for the Assessment of Stroke Outcome
نویسندگان
چکیده
منابع مشابه
Adopting a Patient-Centered Approach to Primary Outcome Analysis of Acute Stroke Trials Using a Utility-Weighted Modified Rankin Scale.
BACKGROUND AND PURPOSE Although the modified Rankin Scale (mRS) is the most commonly used primary end point in acute stroke trials, its power is limited when analyzed in dichotomized fashion and its indication of effect size challenging to interpret when analyzed ordinally. Weighting the 7 Rankin levels by utilities may improve scale interpretability while preserving statistical power. METHOD...
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BACKGROUND AND PURPOSE There is little agreement on how to assess outcome in acute stroke trials. Cutoff scores for the Barthel Index (BI) and modified Rankin Scale (mRS) are frequently arbitrarily chosen to dichotomize favorable and unfavorable outcome. We investigated sensitivity and specificity of BI cutoff scores in relation to the mRS to obtain the optimal corresponding BI and mRS scores. ...
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متن کاملInfluence of stroke infarct location on functional outcome measured by the modified rankin scale.
BACKGROUND AND PURPOSE In the early days after ischemic stroke, information on structural brain damage from MRI supports prognosis of functional outcome. It is rated widely by the modified Rankin Scale that correlates only moderately with lesion volume. We therefore aimed to elucidate the influence of lesion location from early MRI (days 2-3) on functional outcome after 1 month using voxel-base...
متن کاملShift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials.
BACKGROUND AND PURPOSE The SAINT I trial that showed a significant benefit of the neuroprotectant NXY-059 used a novel outcome for acute ischemic stroke trials: a shift toward good functional outcome on the 7-category modified Rankin scale (mRS). METHODS We used the Cochran-Mantel-Haenszel shift test to analyze the distribution of the 90-day mRS outcomes in the NINDS and ECASS-II databases an...
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ژورنال
عنوان ژورنال: Stroke
سال: 2020
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.119.028523